Sister-chromatid cohesion is made during S phase when Eco1 acetylates cohesin. of SCF recruits substrates by interacting with specific sequence motifs (degrons), which often contain phosphorylation sites. Phosphodegrons created by Cdks and other kinases tie SCF to many important cell cycle processes. In yeast, for example, phosphorylation of several cell-cycle regulators by Cdk1 leads to… Continue reading Sister-chromatid cohesion is made during S phase when Eco1 acetylates cohesin.